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500mg tablets of Depakote extended-launch Valproate or valproic acid is made use of primarily to treat epilepsy and bipolar condition and to stop migraine head aches.[21]
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Suicidal feelings or steps is often because of things in addition to medicines. When you've got suicidal thoughts or steps, your Health care supplier might check for other causes.
Divalproex sodium dissociates into the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been set up.
3)]. Given that the Depakote dosage is titrated upward, blood concentrations of phenobarbital and/or phenytoin can be impacted [see Drug Interactions (seven.two)]. Antiepilepsy medicines really should not be abruptly discontinued in sufferers in whom the drug is administered to stop major seizures as a result of powerful risk of precipitating standing epilepticus with attendant hypoxia and menace to lifestyle. In epileptic clients previously obtaining valproic acid therapy, Depakote tablets must be initiated at the identical day by day dose and dosing timetable. Once the affected person is stabilized on Depakote tablets, a dosing schedule of two or 3 times on a daily basis might be elected in chosen individuals.
This is especially essential for Females setting up a pregnancy and for ladies within the onset of puberty; alternative therapeutic selections really should be thought of for these people [see Boxed Warning and Use in Specific Populations (8.1)]. To prevent significant seizures, valproate should not be discontinued abruptly, as This may precipitate standing epilepticus with resulting maternal and fetal hypoxia and risk to existence. Evidence suggests that folic acid supplementation prior to conception and during the very first trimester of pregnancy decreases the risk for congenital neural tube defects in the final inhabitants. It's not necessarily known whether or not the risk of neural tube defects or diminished IQ while in the offspring of girls getting valproate is decreased by folic acid supplementation. Dietary folic acid supplementation each prior to conception And through pregnancy needs to here be routinely proposed for patients applying valproate.
Begin to see the Guidelines to be used that comes with this Medication Guideline for in depth Guidance on how to use Depakote Sprinkle Capsules. For those who overlook a dose of DEPAKOTE ER tablets or DEPAKOTE delayed-release tablets, just take it once you don't forget Except it’s Virtually time for the upcoming dose. Take the following dose at your standard time. Do not acquire 2 doses simultaneously.
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Severe and fatal liver harm continues to be related to valproate, especially during the to start with 6 months of treatment method.
are breastfeeding. Depakote can move into breast milk and could hurt your baby. Speak with your healthcare company about The simplest way to feed your child if you are taking Depakote.
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Minimal platelets. Platelets assist the blood to clot. Bruising easier than usual can be a symptom of lower platelets
This has occurred when DEPAKOTE is taken by itself or by using a medicine identified as topiramate. Phone your well being care service provider For those who have any of such signs.